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R-410A Refrigerant (HFC, R-22 Replacement)
R-410A Refrigerant – Industry Standard HFC
R-410A refrigerant has become the most widely used HFC refrigerant for residential and commercial air conditioning systems. Originally introduced as the primary replacement for R-22, R-410A delivers higher energy efficiency, zero ozone depletion potential, and reliable cooling performance. It is the dominant refrigerant in systems manufactured after 2010.
Common Applications
- Residential split-system air conditioners
- Commercial rooftop and packaged A/C systems
- Heat pumps and ductless mini-split systems
Cylinder Sizes & Packaging
- 25 lb cylinder (standard service size)
- 100 lb cylinder (bulk applications)
- ISO tanks (industrial use)
Key Advantages
- Proven reliability in millions of systems worldwide
- High efficiency for air conditioning and heat pump applications
- Zero ozone depletion potential (compared to HCFC R-22)
Important Notes
- Not compatible with R-22 equipment. R-410A operates at higher pressures and requires systems specifically engineered for it.
- Certification: Purchases may require EPA Section 608 certification. Verify all local and federal regulations before ordering.
Looking for alternatives? Compare R-32 and R-454B for lower GWP options, or browse all HFC refrigerants.

